The ABC transporters ABCB1 (MDR1), ABCC1 (MRP1), and ABCC2 (MRP2) among others are involved in ATP-dependent efflux of drugs or drug-GS conjugates
Why diet matters on GLP-1s GLP-1 medications and dual incretin medications (for example semaglutide and tirzepatide) can increase fullness and slow digestion, which can reduce cravings and portion sizes, but may also trigger GI side effects like nausea, vomiting, heartburn, bloating, diarrhea, and constipation, especially during dose increases
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This is a central mechanism distinct from peripheral vasodilators
Dividing the thigh into quadrants helps establish consistent injection locations, which reduces tissue trauma and bruising across multiple weekly doses