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PYY 136 is a gut hormone that binds to the Y1-R in pancreatic islets and central nervous system (CNS) nuclei that control appetite regulation in the brain including the brainstem area postrema (AP) and nucleus tractus solitarius (NTS), where it has an orexigenic effect 18
Metformin 2500/3000mg a day + Glipizide 20mg/glibenclemide15-20mg/day Gliciazide 320mg/ Glimepride 6-8mg/day + Rosiglitazone 8mg/ Pioglitazone 45mg/day When should Insulin be used in Type 2 diabetes mellitus
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