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MTHFR mutations involve changes in the methylenetetrahydrofolate reductase gene, influencing how the body processes key nutrients like folate (vitamin B9)

The frequency of B12 injections varies based on the severity and cause of deficiency: For significant deficiencies or pernicious anemia, daily or weekly shots may be started, then tapered to monthly maintenance doses

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Vitamin B12 is an essential water-soluble vitamin required for nucleoprotein and myelin synthesis, cell reproduction, normal growth, and normal erythropoiesis

Patutina OA, Gaponova Miroshnichenko SK, Senkova AV et al (2020) Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency