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Researchers are currently investigating whether using GLP-1s leads to a higher proportion of lean mass loss, but the available evidence suggests that people who lose weight while using GLP-1s can still maintain or even improve their muscle function

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Further studies on GLP-1 revealed that the entire GLP-1 molecule when administered had no effect on insulin levels

Early phase response (weeks 1-2) Initial responses to combination therapy typically manifest as reduced inflammation and pain at injury sites

However, since Saxenda (liraglutide) became the first GLP-1 approved for weight loss in 2014, additional options like Wegovy (semaglutide) and Zepbound (tirzepatide) have also been approved for weight management