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Several landmark cardiovascular outcome trials have demonstrated that GLP-1RAs can significantly reduce the risk of major adverse cardiovascular events (MACE), which include cardiovascular death, nonfatal myocardial infarction (heart attack), and nonfatal stroke [43]

Theyre taking away your interest in drinking in the first place, your desire to do that, and thats a very different biological pathway than gastrointestinal side effects

May 2019;86(2):74-78

Greater potency and greater stability from one structural change, which is why the constrained-cyclic approach recurs throughout peptide medicinal chemistry

This means tirzepatide is the first agent to be develop that targets both GIP and GLP-1 hormones