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Human thyroid C-cells appear to express GLP-1 receptors at lower levels than rodent C-cells, suggesting that humans may be less susceptible to GLP-1-mediated thyroid proliferation, though evidence on receptor expression varies

Conversely, an episode of shedding may reveal previously compensated follicular miniaturization, leaving persistent patterned loss after the acute process resolves

For instance, Eli Lilly's obesity treatment tirzepatide activates both GLP-1 and GIP and has demonstrated greater weight loss effects than semaglutide

Improving tendon healing in ruptures

For tirzepatide specifically, common side effects include constipation , diarrhea , headaches , and body aches