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The excess AGEs could lead to non-enzymatic cross-linking of collagen, break the adhesion of osteoblasts to the extracellular matrix and leads to bone fragility ( / mice are mainly used to study atherosclerosis, but ApoE / mice can also be used to study osteoporosis
(9) If left untreated, NAFLD can progress to conditions like cirrhosis, liver failure, or liver cancer
Reich and Hlscher, 2022)
doi:10.1016/j.yrtph.2008.01.004
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