Differential effect of a xanthine oxidase inhibitor on arterial stiffness and carotid atherosclerosis: a subanalysis of the PRIZE study
It offers a good balance between injectable volume and dosing flexibility across the full tirzepatide dose range
Patients with structural heart disease (valvular abnormalities, cardiomyopathy, congenital defects) or a history of sustained arrhythmias should have cardiology clearance and repeat ECG at 46 weeks after starting therapy
However, their resultant increase in erythropoietin and as a consequence hematocrit and blood viscosity [11], which could in part be attributed to the effect of SGLT2i to increase sodium excretion and to decrease plasma volume, could predispose to a slight increase in thrombosis [12], thereby offsetting the reduction in stroke that would otherwise be expected from the blood pressure lowering
Semaglutide may help increase feelings of fullness, support portion control, and reduce cravings