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Ideal candidates The tirzepatide with B6 compound makes the most sense for people who have experienced significant nausea on GLP-1 medications in the past, whether from tirzepatide itself or from semaglutide

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There are two main trials (FIGHT and LIVE trials) demonstrating that treatment with liraglutide increased the risk of adverse heart failure-associated outcomes in patients with heart failure and reduced LVEF [43-45]

Patients taking any of these medications along with semaglutide experience multiple simultaneous hits to b12 absorption