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The STEP 1 trial, for example, reported an average weight loss of 14.9% in participants receiving semaglutide, compared to just 2.4% in the placebo group
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The decrease between the 1970s and the 1980s coincided with the emergence of reninangiotensin system (RAS) blockers, but the conspicuous lack of further improvements after the 1980s highlights the need for additional kidney-protective medications [4]
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