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Previously, Pfizer designed the drug as a twice-daily pill but it faced discontinuation rates of over 50%, possibly due to side effects

Both medications are glucagon-like peptide-1 (GLP-1) receptor agonists, though tirzepatide also activates GIP receptors, which may contribute to slightly stronger average weight loss results in clinical trials

NIH, National Library of Medicine, Office of Dietary Supplements - Vitamin C Fact Sheet for Health Professionals 2

The difference is that GLP-1 users eat less because the drugs suppress their appetites, so the foods they do eat need to be packed with nutrients, Christen said

None of these are deal-breakers on their own, but they add up