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Infants may present with growth failure, irritability, lethargy, muscle weakness, and frequent respiratory infections, while teens may present with pain in weight-bearing joints like the knees, as well as pain in the back, calves, and thighs

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In keeping with the reduced capacity of homocysteine-exposed endothelial cells to inhibit platelet aggregation, Lentz and collaborators demonstrated, using experimental hyperhomocysteinemia (induced by a diet depleted of folate, high in methionine, and choline-free) that the endothelial-dependent vasodilation is impaired in hyperhomocysteinemic primates

The most common MCAS symptoms are: Systemic fatigue, sensitivity to food and medication Respiratory nasal congestion, shortness of breath, asthma, throat swelling Neurological headaches, migraines Mental/emotional decreased concentration, memory

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