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This 'allosteric' approach, which targets a site other than the active site, can theoretically reduce side effects because the drug indirectly alters the receptor's structure to activate it

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Gln plays a crucial role in the energy supply of rapidly dividing cells, such as intestinal epithelial cells and cells of the immune system 23

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Since semaglutide is injected subcutaneously, any bacterial or fungal contamination could cause serious infection