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Mechanisms of cardiorenal effects of sodium-glucose cotransporter 2 inhibitors: JACC state-of-the-art review
Purifying long peptides is difficult, plus these GLP-1 peptide drugs have been modified to include a fatty acid side chain, and lipids themselves can be very difficult to purify, because theyre very hydrophobic, and tend to stick to the [purification] column, says Levine
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Relevantly, the polarization of macrophages may affect the development of inflammation
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