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So the first honest distinction is structural: tesamorelin is a modified full-length analog engineered for resistance to degradation, whereas sermorelin is an unmodified short fragment that reproduces GHRH activity but not GHRH stability

Moreover, IGF-related molecular mechanisms not only play a role in tumor cells but also affect other nontumor cell components in the microenvironment, such as fibroblasts, macrophages and T cells, demonstrating that targeting IGFs alone cannot completely inhibit tumor growth and progression

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J Alzheimers Dis (2010) 19(4):120519