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Ischemic preconditioning confers epigenetic repression of mtor and induction of autophagy through G9a-dependent H3K9 dimethylation

doi: 10.3389/fphar.2021.670155 Received 20 February 2021 Accepted 16 April 2021 Published 12 May 2021 Volume 12 - 2021 Edited by Daniele Torella, University of Catanzaro, Italy Reviewed by Antonella De Angelis, University of Campania Luigi Vanvitelli, Italy Eleonora Cianflone, University of Catanzaro, Italy Updates Copyright 2021 Nusca, Tuccinardi, Pieralice, Giannone, Carpenito, Monte, Watanabe, Cavallari, Maddaloni, Ussia, Manfrini and Grigioni

has received speaking honoraria from Novo Nordisk

Therefore, we hypothesized that the excessive expression of GJs post-APAP exposure in hepsin / mice could be a key factor contributing to the increased severity of liver damage observed following APAP administration

Consistency is the most important thing here