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Simpson et al
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Hormonal Changes Losing weight significantly changes hormones: Leptin Lessens: When leptin levels are regularly low, hunger and craving levels increase
An investigation ratio significantly greater than 0.5 indicates that the rats were spending more time with the novel object
These drugs are currently FDA-approved for type 2 diabetes and obesity not for alcohol use disorder
This model possesses the following advantages in addiction research: Good Face Validity: The increased time animals spend in the drug-paired chamber directly mimics the conditioned craving and drug-seeking behaviors triggered in human addicts upon exposure to drug-associated cues
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