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39 The outcome of these studies reinforces the notion that the intestinal epithelium is essential for separating luminal antigens from mucosal immune components, and that its disruption by altered proliferation/apoptosis ratio can result in immune activation and inflammation (Figure 1)
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CoQ10 exists in two forms: ubiquinone (the oxidised form) and ubiquinol (the reduced, active antioxidant form)
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Rather than supplying additional precursors, it limits NAD+ depletion by inhibiting NNMT, allowing exploration of upstream metabolic control
