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At doses as low as 35 mg/kg, notable changes were observed, potentially affecting physiological function
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UK SmPCs note that in rodent studies, some GLP-1 agonists caused thyroid C-cell tumours, though the clinical relevance in humans is unknown
In a larger crossover study involving 84 healthy adults, daily consumption of 100 g fresh or pasteurized sauerkraut for 4 weeks produced no significant changes in overall gut microbial composition, as assessed by shotgun metagenomic sequencing (Schropp et al., 2025)
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