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This action on fat metabolism may contribute to weight loss beyond the effects of appetite suppression alone and may also underlie some of the improvements seen in lipid profiles and conditions like MASH
Detailed body composition analysis revealed that the weight reduction was predominantly fat mass, with preservation of lean muscle mass that's crucial for maintaining metabolic rate and functional capacity [9]
The general dose escalation path looks like this: Weeks 1-4: 2.5 mg once weekly Weeks 5-8: Increase to 5 mg once weekly, if tolerated Weeks 9-12: Increase to 7.5 mg once weekly, if tolerated and needed Ongoing: Continue increasing by 2.5 mg every 4 weeks until the target maintenance dose is reached
Just like with Zepbound (Tirzepatide), doses should be tailored for each person during their weight loss journey
The threshold at which tirzepatide meaningfully reduces food intake rises as your body acclimates
