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In models where nerves have been transected or crushed, treatment with the peptide has led to accelerated functional recovery, improved nerve conduction, and enhanced histological signs of healing
Patients with electrolyte abnormalities or those experiencing significant gastrointestinal fluid losses also warrant closer monitoring
Jwiak-Bbenista M, Kowalczyk E
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The direct action of GLP-1 which can also be demonstrated in the perfused pancreas, with isolated islets and with beta cell derived cell lines involves activation of the beta cell GLP-1R which couples through the heterotrimeric G-protein Gs to activate adenylyl cyclase and increase intracellular cAMP (27, 65)
