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Is it like surgery
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Changes in appetite may be noticed within the early weeks, while measurable improvements in weight and metabolic health usually become clearer with continued weekly treatment and gradual dose adjustment
doi:10.1038/sj.ejcn.1602188
in vivo, it recapitulates core features of exercise mimetics, including increased energy expenditure at thermoneutrality, a lower respiratory exchange ratio (RER) consistent with enhanced lipid oxidation, and improvements in fat mass and hepatic lipid content in obese mice
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