En comparacin con el placebo, la semaglutida mejor la respuesta a la insulina tanto de la primera como de la segunda fase, con un aumento de 3 y 2 veces, respectivamente, y una capacidad secretoria mxima de las clulas beta despus de una prueba de estimulacin con arginina, en pacientes con diabetes tipo 2
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(2) R T Dorr, R Lines, N Levine, C Brooks, et al (1996) Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study Life Sciences, 1996, Volume 58 (Issue 20), Pages 1777-84
This means that both the onset of full effect when starting treatment and the waning of effect when stopping treatment may take several weeks
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