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Clinicians prescribing BPC-157 off-label do so based on preclinical data, mechanistic plausibility, and patient-reported outcomes, not a regulatory evidence package

Of note, in the SURPASS-4 trial, adjudicated major adverse cardiovascular events (MACE) were not increased with tirzepatide compared with insulin glargine over an extended follow-up period of 52 additional weeks after the main trial period of 52 weeks [21]

Given the benign mechanism of action and the excellent safety profile observed in trials, serious long-term risks seem unlikely

Journal of Enzyme Inhibition and Medicinal Chemistry

This cardiovascular protection has been demonstrated at the 2.4 mg Wegovy dose, not at the lower Ozempic doses