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Discussion and Conclusions This research aimed to perform computational molecular systems integration of oxidative stress with the recently developed in silico model of C1 metabolism in order: 1) to demonstrate the extensibility and scalability of the in silico model of C1 metabolism resident in the CytoSolve Collaboratory, and 2) to explore the effects of oxidative stress on C1 metabolism relative to formaldehyde (HCHO) and glutathione (GSH), a powerful antioxidant and important indicator of oxidative homeostasis in living systems
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