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Additional studies are needed to evaluate safety, efficacy, and proper use of GLP-1 agonists for dermatologic conditions to consider expanding their approval beyond T2DM and weight loss

Pancreatitis should be suspected in patients experiencing persistent, severe abdominal pain, with or without nausea, and GLP-1 RAs should be discontinued if this occurs [128]

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Advanced / Aggressive Protocol (1 mL = ~10.0 mg/mL) Note: The 12 mg dose represents the highest dose tested in Phase 2 trials [3] [4] , producing maximum weight-loss efficacy (~24% body weight at 48 weeks)