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It acts as a selective agonist at the ghrelin receptor (growth hormone secretagogue receptor type 1a, GHS-R1a), the same receptor targeted by the endogenous hormone ghrelin, to stimulate the release of growth hormone (GH) from the anterior pituitary in preclinical models

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Semaglutide (Ozempic, Wegovy) achieves this through a fatty acid chain that binds to albumin in the blood, shielding it from DPP-4, plus an amino acid substitution that further resists breakdown

by decreasing immobility time in the forced swim test [54]

The basal diet and dough particles were pelleted to a proper size (about 0.2 mg per particle) for zebrafish