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Peptide-siRNA nanoparticles targeting NF-kappaB p50 mitigate experimental abdominal aortic aneurysm progression and rupture

Wang X, Qi F, Xing H, Zhang X, Lu C, Zheng J

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Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66