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We found that glutathione and thioredoxin, the major thiol antioxidants, and glutathione and thioredoxin reductases, the enzymes responsible for maintaining them in a reduced state, fell substantially in rodent bone marrow after ovariectomy and were rapidly normalized by exogenous 17- estradiol
Garcia-Ruiz, C
Consequently, similar environmental signals can produce different flavonoid outputs depending on the accompanying stress, illustrating that pathway regulation is determined by network integration rather than by individual signaling pathways
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