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TCB II: 4247kDa protein Essential protein in the delivery of vitamin B12 to cells and tissues The production site of TCB II is primarily hepatocytic, and secondarily endothelial, monocytic and intestinal Functions of vitamin B12: B12 acts as a cofactor for two key enzymatic reactions: Methionine Synthase (cytoplasm): Converts homocysteine methionine Requires methylcobalamin Supports DNA synthesis via the folate cycle (regenerates tetrahydrofolate) Methylmalonyl-CoA Mutase (mitochondria): Converts methylmalonyl-CoA succinyl-CoA Requires adenosylcobalamin Involved in fatty acid and amino acid metabolism Elevated vitamin B12 (hypervitaminemia B12) While vitamin B12 deficiency is commonly discussed, elevated serum B12 (hypercobalaminemia) is less common and often overlooked or misinterpreted
It has been published in the prestigious journal Vaccines (Scopus Q1, Top 10%)
This is the big question most people have when they hear about Vitamin B12 injections for weight loss
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Not a peptide CHEMICAL STRUCTURE Molecular Formula : C 10 H 11 N 2 + Source: PubChem Mechanism of Action 5-Amino-1MQ acts as a highly selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), blocking the methylation of nicotinamide (a form of vitamin B3) using S-adenosyl methionine (SAM) as a methyl donor
