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Because semaglutide is a large molecule, it is difficult for the stomach to absorb
Alternatively, the elution separating the truncated form from the target GLP-1 moiety employing organic modifier could be performed above pH 10.0 simply by a salt component (gradient or isocratically) at eluting conditions
Taking it with only plain water (no more than 4 ounces) on an empty stomach, then waiting 30 minutes before eating, ensures optimal bioavailability and therapeutic effectiveness
2017 Mar;3(1):3-14
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