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Additionally, many of the currently available clinical agents display the always on characteristic, where they illuminate disease sites through self-accumulation rather than being specifically activated by target molecules of interest, which leads to poor imaging contrast and compromised detection accuracy

The Journal of clinical endocrinology and metabolism, 82(5), 14721479

A major limitation of the present study is the cross-sectional design of the analyses, which estimated the associations between AC levels and depression at the same assessment (either baseline or 6-year follow-up), precluding conclusions about causality