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The rate of loss began tapering after week 36, consistent with the metabolic adaptation seen in all obesity pharmacotherapy trials, but the plateau in most participants wasnt reached until approximately weeks 44-48
Furthermore, mitochondrial dysfunction, neuroinflammation, and oxidative stress are central to biochemical events in PD such as S aggregation, dysregulated sirtuin activity, and impaired insulin signaling (Picca et al., 2020)
Most programs look for a qualifying BMI (typically 30, or 27 with a related condition like high blood pressure or prediabetes), and some may require recent lab work to confirm eligibility
Since obesity is considered a chronic condition, many individuals may require continued care to achieve sustained weight loss and its associated health benefits 13
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