Science 379 , eaaw3835 (2023)
Absorbance was read at 490 nm in a microplate reader (Synergy HT BioTek, Winooski, VT, USA)
In cultured human keratinocytes exposed to UVB radiation (a standard oxidative stress model), pre-treatment with 10 nM GHK-Cu resulted in: 2.8-fold increase in glutathione reductase mRNA (the enzyme regenerating reduced glutathione from its oxidized form) 2.3-fold increase in catalase expression (HO decomposition) 1.9-fold increase in ferritin heavy chain (sequestering iron, another Fenton-active metal) 62% reduction in 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, a DNA oxidative damage marker The protective effect disappeared when using copper-free GHK or copper chloride alone, confirming the intact peptide-copper complex is required
URL search params for shareable state Calculator state (peptide selected, vial size, water volume, dose) lives in URL search params
In animal studies, BPC-157 has shown potential for accelerating tendon healing, reducing inflammation, supporting gut lining repair, and protecting organs