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However, as suggested by a previous MR study [23], uric acid is downstream of l-carnitine, i.e., a mediator, so we did not exclude it as an invalid genetic instrument
p53: 800 million years of evolution and 40 years of discovery
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Cardiovascular Diseases Hyperuricaemia has been considered as not only a risk factor for human cardiovascular diseases such as myocardial infarction, hypertension, but also a co-variable of other known risk factors for cardiac deaths and coronary heart disease (So and Thorens, 2010
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