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Why GLP-1 Agonists May Increase Kidney Stone Risk The primary mechanism linking GLP-1 agonists to kidney stones is dehydration
[12] [13] Endogenous GLP-1 has a very short half-life, typically 12 minutes, as it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)
Thats why some people lose weight on a GLP-1 but later find themselves dealing with: Lower energy Slower metabolism Loss of strength Difficulty maintaining results Even more surprising
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