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These continuously generated electrophilic hydroperoxy-phospholipids are neutralized by a specific GSH-dependent peroxidase, glutathione peroxidase 4 (GPX4), which prevents them from damaging membranes and driving ferroptotic cell death (7, 8)

T2DM and obesity are two epidemics that seriously endanger human health

Although it was reported that sKl may exert antioxidative effects in HUVECs by inducing MnSOD (manganese superoxide dismutase) expression via activation of the cAMP/PKA (protein kinase A) pathway, 55 sKL treatment did not affect the PKA activity or SOD (superoxide dismutase) expression in cardiomyocytes isolated from KL (/) mice (Online Figure XVIIIA through XVIIIC)

Studies have shown topical methods to be effective in skin lightening