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Since GSTO1 overexpression has been implicated in drug resistance, particularly to platinum compounds 7,18,19 , we tested the effects of GSTO1 inhibitors in combination with cisplatin in HCT116 cells

Miller TR, et al

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Natural products such as alkaloids, flavonoids, phenolics, and terpenoids exemplify this approach due to their direct antibacterial activity, strong antioxidant effects, anti-biofilm activity, and ability to synergize with antibiotics