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The ability of probenecid to inhibit cAMP accumulation in GLP-1(2836)treated human caECs further supports our finding that GLP-1(2836) works through sAC to increase intracellular cAMP levels (Supplemental Figure 8C)

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While this represents a higher per-treatment cost than oral supplements, the superior absorption and reduced frequency often make injections cost-competitive over time, particularly for those who dont absorb oral forms effectively

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