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Clinical trials show that tirzepatide produces 20-25% more weight loss than semaglutide in some populations, particularly those with genetic variations that blunt GLP-1-only response

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It plays a crucial role in regulating blood sugar levels and is often necessary when lifestyle changes and oral medications are insufficient for maintaining optimal glucose control

they should not be directly compared with results from trials of other agents, as differences in trial design, population, background therapy, and follow-up duration make cross-trial comparisons unreliable