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This phenomenon is commonly referred to as the "nocturnal histamine dump." The body's basal histamine release is governed by core circadian clock genes

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It is naturally present in human blood, saliva, urine, and its plasma concentration declines with age from approximately 200 ng/mL at age 20 to under 80 ng/mL after age 60

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Once approved, the patient is seated comfortably while a healthcare provider inserts an intravenous line into a vein, usually in the arm