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Expression of E-cadherin cell adhesion molecules suppresses melanocyte proliferation, but on the other hand, expression of N-cadherin triggered by trauma or metabolic changes in the microenvironment promotes proliferation and migration of melanocytes, which can then aggregate in nests [4, 6]
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doi: 10.1038/nm.2002 154 DornelesGPda SilvaIBoeiraMCValentiniDFonsecaSGDal LagoPet al
Interference with TGFbeta1-mediated inflammation and fibrosis underlies reno-protective effects of the CB1 receptor neutral antagonists AM6545 and AM4113 in a rat model of metabolic syndrome
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