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Even a basic rotation habit is dramatically better than hitting the same spot every week
The evidence base consists primarily of animal studies and anecdotal reports
Dietary fatty acid palmitate induces endoplasmic reticulum stress, chondrocyte death and cartilage lesions in the knee joint of mice
O'Leary ME, Chahine M (2002): Cocaine binds to a common site on open and inactivated human heart (Nav1.5) sodium channels
And you're avoiding these other metabolites of theophylline and theobromine, and theophylline in particular -- side effect ridden." He continues that there are more stages of metabolites after those two, and by avoiding them, you remove a lot of the longer-lasting side effects
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