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MDHAR, monodehydroascorbate reductase

A complex karyotype including 22q monosomy, recurrent losses involving chromosomes 1, 2, 21, and 17p, trisomy 6p, and ring chromosome 11 have been described in MMNST [3, 4, 10, 17]

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For instance, CR combined with radiotherapy, has been shown to modulate the TME in a triple-negative breast cancer model by decreasing the number of intratumoral Tregs, increasing the CD8 + cell: Treg ratio, and upregulating PD-1 expression on CD8 + T cells