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In summary, tirzepatide was noninferior and superior to semaglutide with respect to the reduction of HbA1c from baseline to 40 weeks (71)

Likewise, multiple large clinical studies with various GLP-1 RAs have shown a more favorable trend in lipid profiles with GLP-1 RAs, although these were not evaluated as the primary outcomes (Table 2)

Intrapancreatic fat deposition has been proposed to represent a key mediator of diseases of both the endocrine (i.e., type 2 diabetes) and exocrine pancreas (including PDAC and acute pancreatitis) 50

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the design is intended to extend half-life and reduce the amyloid-aggregation tendency of native human amylin while retaining amylin-receptor agonist activity