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These mechanisms help explain why GLP-1 receptor agonists are used in approved therapies for type 2 diabetes or weight management, depending on product and jurisdiction 12, 13

Circulating fibroblast growth factor 21 (FGF21) is also implicated in glucagon-induced energy expenditure, as mice lacking FGF21 are protected from this effect [62]

et al., 2023 Geschiedenis De ontwikkeling van Retatrutide bouwt voort op decennia aan onderzoek binnen de peptide-signaleringswetenschap

Figure 2: Structural formula of Liraglutide Figure 3: DPP-4 cleavage site on GLP-1 Liraglutides design achieved two breakthroughs: 1

[1] Various mechanisms for the hypopigmentary effect of glutathione have been proposed, with inhibition of tyrosinase being the most important [Box 2]