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84 Based on this phenomenon, trials were developed to combine anti-IGF-1R with a targeted appropriate treatment as follows: anti-IGF-1R plus chemotherapy for TNBC, anti-IGF-1R plus hormonal therapy such SERMs for ER or PgR positive, and anti-IGF-1R plus aromatase inhibitor for postmenopausal patients

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60,61 Mammalian ALPs are zinc-containing metalloenzymes that function as dimeric molecules

Studies focus on optimizing regular, parallel collagen filament cross-linking while actively discouraging the disorganized fibrotic accumulation typical of scarring