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GLP-1R agonists now appear to be efficacious in reducing heart disease risk and in treating certain chronic kidney diseases, expanding their likely future use

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5 This was similar to ACHIEVE-1, in which 2.2% to 5.7% of participants in the orforglipron groups discontinued due to GI adverse effects, in contrast to no participants in the placebo group

Storage & Handling Store in a cool, dry, stable environment Protect from light, heat, and moisture Avoid repeated freezethaw cycles Reconstitute only in a laboratory setting using sterile bacteriostatic water or approved solvents Handle with appropriate laboratory PPE and safety procedures Refer to the Certificate of Analysis for full handling guidance