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Kaufman et al (2015) noted significant structural differences in the brains of 10 AAS users vs 10 matched, non-AAS using weightlifters that could lead to increased risk of neurodegenerative processes
Sensory suppression during feeding
The bidirectional effects of NMDA receptor antagonism on feeding could potentially diminish the weight-lowering efficacy of systemic exposure to NMDA receptor antagonists
However, cross-trial comparison consistently shows Tirzepatide producing 36% greater body weight reduction at maximum doses
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