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The central difference is receptor selectivity

When energy intake drops, the body slows its metabolic rate as a protective response, making exercise feel harder as it conserves energy for essential processes

Any severe or persistent vomiting, signs of dehydration, severe abdominal pain, or symptoms suggestive of pancreatitis (persistent severe abdominal pain radiating to the back) warrant immediate medical evaluation and possible suspension of treatment

Changes in the fungal communities of PSC patients Current evidence indicates significant alterations in the gut mycobiome of patients with PSC (Table 3)

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